INTRODUCTION

EMESET contains Ondansetron which belongs to a group of medicines called anti-emetics, which help to stop feeling or being sick. It is indicated to prevent and treat nausea and vomiting induced by cytotoxic therapy and radiotherapy and post-operative nausea and vomiting. This medicine works by blocking the action of serotonin levels in the brain which causes nausea and vomiting during chemotherapy or any other surgery.

Cytotoxic chemotherapy triggers the release of serotonin from the enterochromaffin cells of the small intestine. The released serotonins stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Ondansetron is a selective 5-HT3 receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Always take EMESET exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your doctor will decide the right dose depends on your child’s age and body weight. The common side effects are headache, constipation and dizziness.

USES OF EMESET

• Cancer chemotherapy-induced nausea and vomiting


• Postoperative nausea and/or vomiting

HOW EMESET WORKS

EMESET is a selective 5-HT3-receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

DIRECTIONS FOR USE

Always take EMESET exactly as your doctor has told you. Do not mix medicine with anything (even water) before swallowing it. Shake well before use. It can be taken with or without food.

SIDE EFFECTS OF EMESET

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• Apomorphine (used to treat Parkinson’s Disease)


• Phenytoin, carbamazepine (used to treat epilepsy)


• Rifampicin, erythromycin (an antibiotic)


• Tramadol (used to treat pain)


• Medicines used to treat heart problems such as abnormal heart beats (anti-arrhythmics) and high blood pressure (betablockers)


• Anthracyclines, trastuzumab (used to treat cancer)


• Ketoconazole (used to treat fungal infection)